act(p(HGNC:MAPK1)) association bp(MESH:"Neuronal Plasticity")

PubMed:19126755

Recent studies have supported a role for ERK and CREB activity in neural plasticity associated with nicotine addiction (71, 381, 484). It has also been proposed that the ERK and JAK-2/STAT-3 signaling pathways contribute to the toxic effects of nicotine in skin cells (42), and other pathways contribute to the effects of nicotine and other nicotinic ligands on inflammatory responses as described below.

Related Edges 11

• act(a(CHEBI:nicotine)) association a(MESH:Skin)
• a(MESH:Skin) association act(a(CHEBI:nicotine))
• bp(GO:"ERK1 and ERK2 cascade") increases act(a(CHEBI:nicotine))
• bp(GO:"receptor signaling pathway via JAK-STAT") increases act(a(CHEBI:nicotine))
• bp(MESH:"Neuronal Plasticity") association act(p(FPLX:CREB))
• bp(MESH:"Neuronal Plasticity") association act(p(HGNC:MAPK1))
• act(p(FPLX:CREB)) association bp(MESH:"Neuronal Plasticity")
• act(p(FPLX:CREB)) association path(MESH:"Tobacco Use Disorder")
• act(p(HGNC:MAPK1)) association path(MESH:"Tobacco Use Disorder")
• path(MESH:"Tobacco Use Disorder") association act(p(HGNC:MAPK1))
• path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CREB))

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