act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association p(HGNC:JAK2)

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PubMed:19293145

JAK-2, another early target in the nicotine neuroprotection pathway that may mediate signaling between the nAChR and the PI3K pathway (Shaw et al., 2002), may link nAChR activation with the JAK/signal transducer and activator of transcription 3 (STAT-3) protective pathway. JAK-2 is also activated by nicotine in non-neuronal cells such as nAChR-bearing keratinocytes (Arredondo et al., 2006). In a microarray study, expression of 8 of 33 JAK/STAT pathway genes was altered when human bronchial epithelial cells were exposed to 5 microM nicotine for 4 to 10 h (Tsai et al., 2006). Thus, the JAK-2/STAT-3 pathway is activated by exposure to nicotine.

Related Edges 7

• act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection)
• act(a(CHEBI:nicotine)) association act(p(HGNC:STAT3))
• act(p(HGNC:STAT3)) association p(HGNC:JAK2)
• act(p(HGNC:STAT3)) association act(a(CHEBI:nicotine))
• p(HGNC:JAK2) increases act(a(CHEBI:nicotine))
• p(HGNC:JAK2) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
• p(HGNC:JAK2) association act(p(HGNC:STAT3))

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