p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A))

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PubMed:22908190

Pathological rab5 activation, which in Down syndrome is dependent on bCTF generation (Jiang et al. 2010), can up-regulate endocytosis in a manner functionally equivalent to the elevated endocytosis associated with increased synaptic activity, which is considered a source of Ab generation (Cirrito et al. 2008).

Related Edges 5

• a(CHEBI:"amyloid-beta") positiveCorrelation bp(GO:endocytosis)
• act(a(GO:synapse)) positiveCorrelation bp(GO:endocytosis)
• bp(GO:endocytosis) positiveCorrelation a(CHEBI:"amyloid-beta")
• bp(GO:endocytosis) positiveCorrelation act(a(GO:synapse))
• act(p(HGNC:RAB5A)) increases bp(GO:endocytosis)

MeSH

Down Syndrome

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