p(HGNC:RAB4A) increases complex(a(GO:"early endosome"), a(GO:"late endosome"))

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PubMed:22908190

Genes related to endocytosis, such as Rab5,Rab7, and Rab4, are among the earliest groups to showup-regulated transcription in AD(Ginsberg et al. 2010), and their corresponding proteins are abnormally recruited to endosomes, where they promote fusion and abnormal enlargement of early and late endosomes (Cataldo et al. 1997, 2008).

Related Edges 14

• bp(GO:"regulation of endosome size") association p(HGNC:RAB7A)
• bp(GO:"regulation of endosome size") association p(HGNC:RAB5A)
• bp(GO:"regulation of endosome size") association p(HGNC:RAB4A)
• p(HGNC:RAB4A) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:RAB4A) association bp(GO:"regulation of endosome size")
• p(HGNC:RAB5A) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:RAB5A) increases complex(a(GO:"early endosome"), a(GO:"late endosome"))
• p(HGNC:RAB5A) association bp(GO:"regulation of endosome size")
• p(HGNC:RAB7A) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:RAB7A) increases complex(a(GO:"early endosome"), a(GO:"late endosome"))
• p(HGNC:RAB7A) association bp(GO:"regulation of endosome size")
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB7A)
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB5A)
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB4A)

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