a(CHEBI:"amyloid-beta") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))

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PubMed:19293145

Tg2576 mice expressing human Abeta show reduced [3H]cytisine binding (a label of nAChRs) in the cortex at 17 months after birth (Apelt et al., 2002). In contrast, however, levels of alpha7 or alpha4 subunits were unchanged in double-mutant Swedish APP/PS-1 mice as determined by radiolabeled cytosine (alpha4beta2) or alpha-bungarotoxin (alpha7) binding (Marutle et al., 2002).

Related Edges 2

• path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna7)
• path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna4)

MeSH

Cerebral Cortex

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