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  3. a(MESH:"3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo(3.2.0)heptane") increases act(p(HBP:"alpha-4 beta-2 nAChR"))

a(MESH:"3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo(3.2.0)heptane") increases act(p(HBP:"alpha-4 beta-2 nAChR"))

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Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0

This document contains the curation of the review article Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system by Taly et al. 2009

Provenance

PubMed:19721446

Both initiatives were successful: new compounds — A-366833 and ABT-894 — with improved α4β2 selectivity and a broad spectrum of analgesic efficacy without adverse effects were identified236. ABT-894 was chosen to go into Phase ii clinical trials but the results were disappointing, and the development of this compound for neuropathic pain has been discontinued. The compound remains in clinical trials for ADHD.

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