bp(GO:"one-carbon metabolic process") decreases p(HGNC:APP, pmod(Ph, Thr, 668))

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PubMed:24653673

Remarkably, impairment of one-carbon metabolism in animal models can reproduce AD-like pathological features: accumulation of P-tau (Sontag et al.,2007; Zhang et al.,2008; Wei et al.,2011); enhanced amyloidogenesis (Pacheco-Quinto et al.,2006; Zhang et al.,2009; Zhuo et al.,2010; Zhuo and Pratico,2010); increased phosphorylation of APP at the regulatory Thr-668 site (Sontag et al.,2007; Zhang et al.,2009); increased sensitivity to amyloid toxicity (Kruman et al.,2002); and cognitive impairment (Bernardo et al.,2007; Wei et al.,2011; Rhodehouse et al., 2013).

Related Edges 4

• bp(GO:"one-carbon metabolic process") decreases p(HGNC:MAPT, pmod(Ph))
• bp(GO:"one-carbon metabolic process") decreases bp(HBP:amyloidogenesis)
• bp(GO:"one-carbon metabolic process") decreases bp(GO:cognition)
• bp(GO:"one-carbon metabolic process") decreases act(a(CHEBI:"amyloid-beta"))

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