act(p(HGNC:NOS1)) increases a(CHEBI:"nitric oxide")

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PubMed:19293145

Nicotine also activates ERK in non-neuronal cells such as pancreatic acinar cells (Chowdhury et al., 2007) and vascular smooth muscle cells (Kanda and Watanabe, 2007), although it is not known in those cases which nAChR subtypes are involved. In the cortex and hippocampus of mice, nicotine’s inhibition of MAPK (shown by RNAi reduction of alpha7 expression to be alpha7-dependent) prevents activation of nuclear factor- kappaB and c-Myc, also thereby reducing the activity of inducible nitric-oxide synthetase and NO production and decreasing Abeta production (Liu et al., 2007).

Related Edges 6

• a(CHEBI:nicotine) increases bp(GO:"MAPK cascade")
• bp(GO:"MAPK cascade") increases act(p(HGNC:MYC))
• bp(GO:"MAPK cascade") increases act(p(FPLX:NFkappaB))
• bp(GO:"MAPK cascade") increases act(p(HGNC:NOS1))
• bp(GO:"MAPK cascade") increases a(CHEBI:"amyloid-beta")
• p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade")

Cell Ontology (CL)

pancreatic acinar cell

Cell Ontology (CL)

vascular associated smooth muscle cell

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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