path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT)

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PubMed:25514383

Dementia is a debilitating condition frequent in ageing populations, and Alzheimer's Disease (AD) accounts for 70% of all dementia cases. AD is characterized by neuropathological hallmarks consisting of an accumulation of Amyloid beta peptide (Ab) in extracellular plaques, intracellular deposits of tau protein, neuronal loss and, more recently, a prominent synaptic loss was identified (Braak and Braak,1991; Masliah et al., 2001; Selkoe,1991; Spires-Jones and Hyman, 2014)

Related Edges 11

• a(GO:synapse) negativeCorrelation path(MESH:"Alzheimer Disease")
• bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease")
• bp(GO:aging) association path(MESH:Dementia)
• p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:"Alzheimer Disease") association path(MESH:Dementia)
• path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid")
• path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death")
• path(MESH:"Alzheimer Disease") negativeCorrelation a(GO:synapse)
• path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:Dementia) association bp(GO:aging)
• path(MESH:Dementia) association path(MESH:"Alzheimer Disease")

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