p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A))

PubMed:22908190

Recently, these effects of increased App dosage were shown to be mediated specifically by the b-cleaved carboxy-terminal fragment of APP, bCTF (Jiang et al. 2010), which binds to a complex of signaling molecules on endosomes that pathologically activates rab5 (S Kim and RA Nixon, unpubl.).

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