p(HGNC:DNAJA1) increases a(HBP:"huntingtin aggregates")

View Subject View Object

PubMed:25437566

These included all subunits of the CCT/TRiC complex (except CCT5); HSP40 and HSP70 family members DNAJA1 (HDJ-2), DNAJA4, HSPA8 (HSC70), and HSPA14 (Figures 5B and 5C); and the TPR-domain APC/C subunits CDC23 and CDC27 that, upon knockdown, led to significantly elevated aggregation (Figure S5B).

Related Edges 7

• p(FPLX:"CCT_complex") increases a(HBP:"huntingtin aggregates")
• p(HGNC:CCT5) causesNoChange a(HBP:"huntingtin aggregates")
• p(HGNC:CDC23) increases a(HBP:"huntingtin aggregates")
• p(HGNC:CDC27) increases a(HBP:"huntingtin aggregates")
• p(HGNC:DNAJA4) increases a(HBP:"huntingtin aggregates")
• p(HGNC:HSPA14) increases a(HBP:"huntingtin aggregates")
• p(HGNC:HSPA8) increases a(HBP:"huntingtin aggregates")

MeSH

Brain

MeSH

Alzheimer Disease

MeSH

Huntington Disease

MeSH

Parkinson Disease

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---