p(HGNC:CD55) decreases path(MESH:Hemolysis)

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PubMed:26875449

This scenario may resemble that of paroxysmal nocturnal hemoglobinuria patients, who can be treated with complement C5- blocking antibody eculizumab [80]; in this example, extravascular hemolysis has been shown to occur in a small number of these patients despite treatment. It has been suggested that this is due to erythrophagocytosis of red blood cells deficient in the C3d-opsonized complement regulators – CD55 and CD59 [81,82].

Related Edges 1

• p(HGNC:CD59) decreases path(MESH:Hemolysis)

Cell Ontology (CL)

erythrocyte

MeSH

Malaria

Text Location

Review

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