a(CHEBI:heme) increases p(MGI:F3)

PubMed:26875449

In contrast to the anticoagulant effect of heme on the intrinsic and terminal pathways of coagulation, heme can also trigger the extrinsic pathway of coagulation by upregulating tissue factor (TF) on the surface of human endothelial cells in vitro, as well as on leukocytes and perivascular cells in mice [50,51].

MeSH

Anemia, Sickle Cell

Text Location

Review

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.