act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection)

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PubMed:19293145

There is evidence that nicotine’s neuroprotective effects can be mediated through tumor necrosis factor-alpha (TNF-alpha). Application of either nicotine or TNF-alpha protects cultured mouse embryonic cortical neurons from N-methyl-D-aspartate (NMDA) toxicity, but coapplication of both does not.

Related Edges 4

• act(a(CHEBI:"N-methyl-D-aspartic acid")) increases path(HBP:neurotoxicity)
• a(CHEBI:nicotine) decreases act(a(CHEBI:"N-methyl-D-aspartic acid"))
• p(HGNC:TNF) increases act(a(CHEBI:nicotine))
• p(HGNC:TNF) decreases act(a(CHEBI:"N-methyl-D-aspartic acid"))

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