p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 290))

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PubMed:24869773

An example of a spectrum identifying K311 as a site of dimethylation at 2.2 ppm mass accuracy is shown in Fig. 2B. This residue was reported as a possible methylation site in AD-brain derived tau protein on the basis of Edman degradation years ago [36]. It resides within the “PHF6” motif of the MTBR, which has been reported to mediate the aggregation propensity of recombinant monomeric tau in vitro [6, 37]. Other methylation sites within the MTBR include K259, K290, and K353, each of which lies in a KXGS motif associated with AMP-activated protein kinase mediated regulation of microtubule binding [38]. Within the N-terminal projection domain, Lys methylation was detected at K24, K44, K67, and K190 (Fig. 1).

Related Edges 15

• p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 190))
• p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 24))
• p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 259))
• p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 353))
• p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 44))
• p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 67))
• p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me2, Lys, 311))
• p(HGNC:MAPT, pmod(Me, Lys, 190)) association p(HGNC:MAPT)
• p(HGNC:MAPT, pmod(Me, Lys, 24)) association p(HGNC:MAPT)
• p(HGNC:MAPT, pmod(Me, Lys, 259)) association p(HGNC:MAPT)
• p(HGNC:MAPT, pmod(Me, Lys, 290)) association p(HGNC:MAPT)
• p(HGNC:MAPT, pmod(Me, Lys, 353)) association p(HGNC:MAPT)
• p(HGNC:MAPT, pmod(Me, Lys, 44)) association p(HGNC:MAPT)
• p(HGNC:MAPT, pmod(Me, Lys, 67)) association p(HGNC:MAPT)
• p(HGNC:MAPT, pmod(Me2, Lys, 311)) association p(HGNC:MAPT)

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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