a(CHEBI:"amyloid-beta") increases r(MGI:Chrna3)

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PubMed:19293145

In addition, APP or APP/PS-1 double-mutant mice have normal or even enhanced levels of ChAT and an unchanged cholinergic cell count (Hernandez et al., 2001). However, a double-mutant mouse expressing the Swedish APP and overexpressing human AChE showed enhanced mRNA levels of alpha7 in brain and adrenal medulla, although in brain tissue this enhancement declined with age. In this same mouse, there was no alteration in mRNA levels for alpha4, and an increase in alpha3 has also been observed in the brain and the adrenal medulla (Mousavi and Nordberg, 2006), a pattern similar to that seen in Abeta single-mutant mice (Bednar et al., 2002), suggesting that it is not attributable to the human AChE.

Related Edges 3

• a(CHEBI:"amyloid-beta") increases p(MGI:Chat)
• composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) increases r(MGI:Chrna7)
• composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) causesNoChange r(MGI:Chrna4)

MeSH

Adrenal Medulla

MeSH

Brain

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