a(CHEBI:heme) increases p(HGNC:TLR4)

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PubMed:26875449

Most studies concerning the pathophysiological roles of heme have focused on the protective effect of the heme-degrading enzyme, heme oxygenase 1 (HO-1) [25] (Box 2), and on the effect of this danger-associated molecule on cells, leading to oxidative stress, TLR4 signaling [26,27], and NLRP3 inflammasome activation [28] (Box 4).

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• a(CHEBI:heme) increases bp(MESH:"Oxidative Stress")
• a(CHEBI:heme) increases p(HGNC:NLRP3)

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