p(HGNC:ADAM10) decreases path(MESH:"Plaque, Amyloid")

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PubMed:22122372

Moderate neuronal over-expression of human ADAM10 increases sAPP-alpha production while reducing Abeta generation/ plaque formation in mice carrying the human APP V717I mutation, while expression of a catalytically-inactive form of the ADAM10 mutation increases the size and number of amyloid plaques in mouse brains (Postina et al. 2004)

Related Edges 2

• p(HGNC:ADAM10) increases a(HBP:HBP00067)
• p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta")

Confidence

High

MeSH

Neurons

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