p(HGNC:MAPT, var("p.Arg5Leu")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT))

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PubMed:26631930

Another mutation (R5H or R5L) outside the microtubule-binding domain disrupts the binding of tau to the p150 subunit of the dynactin complex — an essential cofactor for the microtubule motor dynein —thereby possibly interfering with general axonal transport

Related Edges 3

• p(HGNC:MAPT, var("p.Arg5His")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT))
• p(HGNC:MAPT, var("p.Arg5His")) decreases bp(GO:"axonal transport")
• p(HGNC:MAPT, var("p.Arg5Leu")) decreases bp(GO:"axonal transport")

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