p(HGNC:DNAJA1) decreases a(CHEBI:"amyloid-beta polypeptide 42")

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PubMed:25437566

This functional screen identified 18 genes (Figure 3D), corresponding to ten ATP-dependent chaperones, HSC70 (hsp-1), HSP90 (daf-21), and eight subunits of the CCT/TRiC chaperonin complex; the co-chaperones, HSP40 (dnj-12) and CDC37 (cdc-37); and the TPR-domain pro- tein STI1 that upon knockdown significantly enhanced A b 42 pro- teotoxicity (Figure 3D).

Related Edges 4

• p(FPLX:"CCT_complex") decreases a(CHEBI:"amyloid-beta polypeptide 42")
• p(FPLX:HSP90) decreases a(CHEBI:"amyloid-beta polypeptide 42")
• p(HGNC:HSPA8) decreases a(CHEBI:"amyloid-beta polypeptide 42")
• p(HGNC:STIP1) decreases a(CHEBI:"amyloid-beta polypeptide 42")

MeSH

Brain

MeSH

Alzheimer Disease

MeSH

Huntington Disease

MeSH

Parkinson Disease

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