path(HP:"Paroxysmal nocturnal hemoglobinuria") association path(MESH:Hemolysis)

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PubMed:29956069

Inhibition of the terminal complement cascade by eculizumab (inhibits the cleavage of C5 into C5a und C5b and thus the formation of the membrane attack complex 8, MAC C5b-C9) for the treatment of hemolytic paroxymal nocturnal hemoglobinuria (PNH) significantly prevented PNH-related symptoms in patients including abnormal thrombophilia, red blood cell destruction, and the extent of hemolysis [76].

Related Edges 6

• a(MESH:eculizumab) decreases path(HP:"Paroxysmal nocturnal hemoglobinuria")
• path(HP:"Hemolytic anemia") association path(HP:"Paroxysmal nocturnal hemoglobinuria")
• path(HP:"Paroxysmal nocturnal hemoglobinuria") association path(MESH:Thrombophilia)
• path(HP:"Paroxysmal nocturnal hemoglobinuria") association path(HP:"Hemolytic anemia")
• path(MESH:Hemolysis) association path(HP:"Paroxysmal nocturnal hemoglobinuria")
• path(MESH:Thrombophilia) association path(HP:"Paroxysmal nocturnal hemoglobinuria")

Cell Ontology (CL)

erythrocyte

MeSH

Liver

MeSH

Sepsis

Text Location

Review

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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