complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) directlyIncreases p(HGNC:MAPT, pmod(Ub))

PubMed:14612456

These data suggest a model by which phosphorylated tau is bound to a chaperone and the complex is recognized by the E3 Ub ligase CHIP. We further examined whether recombinant GST-CHIP ubiquitinates phosphorylated tau in vitro in the presence of UbcH5B and Hsc70. Ubiquitination of phosphorylated tau was detected as high molecular weight bands by immunoblotting with 5E2 in the presence of UbcH5B and Hsc70 (Fig. 2e).

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.