a(CHEBI:nicotine) decreases act(p(HBP:"alpha-4 beta-2 nAChR"))

PubMed:19126755

In particular, repeated self-administration produces the upregulation of high-affinity (alpha4beta2) nAChR expression, reduces receptor function due to desensitization and, in most cases, imparts developmental tolerance. Additional changes imposed by nicotine abuse range from reinforcement to physical discomfort associated with withdrawal including craving, anxiety, and a multitude of other less than desirable sensations of autonomic dysfunction when use is stopped.

Related Edges 3

• a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR")
• a(CHEBI:nicotine) increases path(MESH:Craving)
• a(CHEBI:nicotine) increases path(MESH:Anxiety)

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