a(CHEBI:"reactive oxygen species") increases act(p(FPLX:"IKK_complex"))

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PubMed:27288790

Under different envi- ronmental conditions such as Aβ/ROS/cytokines accumulation, the IκB kinase (IKK) complex becomes activated and mediates the phosphoryla- tion of IκBs, then IκBs are degradated and the remaining NF-κB dimer is activated and thus translocates to the nucleus where it binds to the DNA consensus sequence of various target genes [9–11].

Related Edges 7

• a(HBP:"amyloid-beta aggregates") increases act(p(FPLX:"IKK_complex"))
• a(MESH:Cytokines) increases act(p(FPLX:"IKK_complex"))
• act(p(FPLX:NFkappaB)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
• act(p(FPLX:NFkappaB)) increases complex(a(MESH:DNA), p(FPLX:NFkappaB))
• act(p(FPLX:"IKK_complex")) increases p(FPLX:IKB, pmod(Ph))
• deg(p(FPLX:IKB)) increases act(p(FPLX:NFkappaB))
• p(FPLX:IKB, pmod(Ph)) increases deg(p(FPLX:IKB))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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