p(HGNC:CCL2) increases path(MESH:Thrombosis)

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PubMed:25307023

Pro-inflammatory cytokines and chemokines [e.g., inter leukin 1B (IL1B), CXCL8 (also termed IL8), TNF and chemokine (C-C motif) ligand 2 (CCL2, also termed MCP1)], are upregulated in haemolytic disorders such as SCD (Qari et al, 2012). This pro-inflammatory cytokine milieu is crucial in mediating the pro-coagulant effects of vascular endothelial cells and promotes localized inflammation and thrombosis (Qari et al, 2012).

Related Edges 7

• p(HGNC:CCL2) increases path(MESH:Inflammation)
• p(HGNC:CXCL8) increases path(MESH:Inflammation)
• p(HGNC:CXCL8) increases path(MESH:Thrombosis)
• p(HGNC:IL1B) increases path(MESH:Inflammation)
• p(HGNC:IL1B) increases path(MESH:Thrombosis)
• p(HGNC:TNF) increases path(MESH:Inflammation)
• p(HGNC:TNF) increases path(MESH:Thrombosis)

Cell Ontology (CL)

endothelial cell

MeSH

Plasma

MeSH

Urine

MeSH

Anemia, Hemolytic, Autoimmune

Text Location

Review

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