g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")

View Subject View Object

PubMed:22908190

High dietary LDL-cholesterol and overexpression of its receptor ApoE (particularly ApoE 14) elevate bCTF levels (Ji et al. 2006; Cossec et al. 2010), and these levels are also elevated in NPC, DS, and AD, particularly in early-onset forms of AD caused by certain mutations of APP.

Related Edges 3

• a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
• p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4")
• p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol")

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---