path(MESH:Aging) decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")

PubMed:19126755

First, age-related nAChR subunit expression decline was observed in both strains, and this was dominated by diminished alpha4 nAChR expression. Second, long-term (12 mo) oral nicotine failed to reduce the age-related decline in the number of neurons expressing alpha4 nAChR subunits, although the neurons that remained exhibited larger processes with more varicosities than age-matched controls (165, 396). Acute nicotine treatment (alpha6 wk of oral nicotine) of aged mice had no measurable influence on nAChR expression, neuronal viability, or dendritic complexity (e.g., Ref. 396)

Related Edges 3

• a(CHEBI:nicotine) causesNoChange p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
• a(CHEBI:nicotine) causesNoChange p(MGI:Chrna4)
• path(MESH:Aging) decreases p(MGI:Chrna4)

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