p(HGNC:BECN1, frag("?")) association a(GO:"neurofibrillary tangle")

View Subject View Object

PubMed:29758300

For example, levels of Beclin 1, a key component of the class III type phosphoinositide 3-kinase/VPS34 complex essential to the pre-autophagosomal structure (PAS), has been suggested to be reduced in AD brains [16,17], with Rohn et al. demonstrating the cleavage of Beclin 1 by caspase-3 in the AD brain and colocalization of the cleaved product with NFTs [16].

Related Edges 4

• a(GO:"neurofibrillary tangle") association p(HGNC:BECN1, frag("?"))
• p(HGNC:BECN1) negativeCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:CASP3) increases p(HGNC:BECN1, frag("?"))
• path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:BECN1)

MeSH

Brain

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---