a(HBP:HBP00006) decreases act(complex(GO:"proteasome complex"))

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PubMed:30116051

Both aggregates and mutant forms of tau likewise block the proteasome, and its ability to degrade hyper- phosphorylated and oligomeric tau is reduced compared with its ability to degrade physiological tau 3,55,68 .

Related Edges 3

• complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT))
• p(HGNC:MAPT, pmod(HBP:HBP00007)) decreases deg(p(HGNC:MAPT))
• p(HGNC:MAPT, var("?")) decreases act(complex(GO:"proteasome complex"))

MeSH

Alzheimer Disease

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