p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Val717Phe")) decreases path(MESH:"Spatial Memory")

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PubMed:25514383

This AD model displays spatial memory deficit at 13-16 months of age, while APP-alpha7KO mice did not exhibit any memory deficit, suggesting that the absence of the alpha7 subunit of the nicotinic receptor protects against the behavioural deficit caused by expression of the mutated forms of APP in this AD model

Related Edges 1

• p(MGI:Chrna7) decreases path(MESH:"Spatial Memory")

MeSH

Alzheimer Disease

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