p(HGNC:KEAP1) increases complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2))

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PubMed:29121589

NRF2 is regulated principally by two different mechanisms. The best established mechanism is the control of protein stability by Kelch-like ECH-associated protein 1 (KEAP1). KEAP1 is an ubiquitin E3 ligase substrate adapter for a Cullin3/Rbx1-dependent E3 ubiquitin ligase complex; henceforth binding of KEAP1 to NRF2 mediates ubiquitination and subsequent proteasomal degradation of NRF2 [7].

Related Edges 2

• complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) increases p(HGNC:NFE2L2, pmod(UbPoly))
• p(HGNC:NFE2L2, pmod(UbPoly)) increases deg(p(HGNC:NFE2L2))

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