bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:CCNE1)
Consistent with the notion that cyclin E is targeted by the Parkin ligase complex is the finding that Parkin deficiency leads to accumulation of cyclin E in cultured postmitotic neurons exposed to the glutamatergic excitotoxin kainite and promotes their apoptosis.
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.