a(CHEBI:heme) increases p(PFAM:ubiquitin)

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PubMed:25301065

Beyond this common protein expression signature, the toxic heme response of Hmox1 (− /−) MEF cells was uniquely characterized by a cluster of strongly upregulated proteins. Within this cluster we identified ubiquitin, the ubiquitin adaptor protein sequestosome/p-62 (Sqstm1), a number of heat shock proteins, as well as antioxidant defense proteins (i.e., peroxiredoxins, glutathione-S-transferase, and thioredoxin reductase).

Related Edges 4

• a(CHEBI:heme) increases p(MGI:Sqstm1)
• a(CHEBI:heme) increases complex(p(MGI:Prdx1), p(MGI:Prdx2), p(MGI:Prdx3), p(MGI:Prdx4), p(MGI:Prdx5), p(MGI:Prdx6))
• a(CHEBI:heme) increases p(INTERPRO:"Glutathione Transferase family")
• a(CHEBI:heme) increases p(INTERPRO:"Thioredoxin reductase")

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