bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Proteostasis Deficiencies")

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PubMed:29024336

Interestingly, although tau-P301L was not degraded in lysosomes, blockage of CMA promoted accumulation of this protein variant, albeit at significantly lower levels than WT and A152T. We propose that overall loss of proteostasis as a consequence of CMA blockage could indirectly affect clearance of tau-P301L through other systems

Related Edges 2

• bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Pro301Leu")))
• path(MESH:"Proteostasis Deficiencies") decreases deg(p(MGI:Mapt, var("p.Pro301Leu")))

MeSH

Lysosomes

Confidence

Medium

MeSH

Brain

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