p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) positiveCorrelation a(HBP:"amyloid-beta oligomers")

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PubMed:30145931

In addition, it has been reported that in cultured neurons, Aβ oligomers induce MAPT missorting into the somatodendritic compartment, and the missorted MAPT is phosphorylated mainly at the 12E8 (p-S262/p-S356) and AT8 (p-S202/p-T205) sites [6].

Related Edges 12

• a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:Dendrites))
• a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
• a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356))
• a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
• a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205))
• p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(HBP:"amyloid-beta oligomers")
• p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:"amyloid-beta oligomers")
• p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation a(HBP:"amyloid-beta oligomers")
• p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation a(HBP:"amyloid-beta oligomers")
• a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))
• a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
• p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) positiveCorrelation a(HBP:"amyloid-beta oligomers")

Confidence

Medium

MeSH

Dendrites

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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