p(MGI:Mapt, var("p.Pro301Leu")) decreases bp(GO:"late endosomal microautophagy")

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PubMed:29024336

Contrary to WT tau, which accumulates in e- MI-defective cells, intracellular levels of A152T and P301L tau did not change in cells knocked down for Vps4, suggesting that both point mutations in tau compromise its ability to undergo degradation by this pathway (Fig. 2a,b)

Related Edges 4

• bp(GO:"late endosomal microautophagy") increases deg(a(HBP:HBP00053))
• p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy")
• p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt, var("p.Ala152Thr")))
• p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt, var("p.Pro301Leu")))

Confidence

High

MeSH

Brain

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