p(HGNC:GSK3B) negativeCorrelation bp(GO:memory)

View Subject View Object

PubMed:24355211

Nuclear factor erythroid-2-related factor 2 (Nrf2) is a transcription factor known to increase the level of many antioxidants, including glutathione-S transferase (GST), and is negatively regulated by the activity of GSK-3β. Our results indicated the increased nuclear localization of Nrf2 and level of GST, suggesting the increased activity of the transcription factor as a result of GSK-3β suppression, consistent with the decreased oxidative stress observed. Consistent with the improved learning and memory, and consistent with GSK-3b being a tau kinase, we observed decreased tau phosphorylation in brain of GAO-treated SAMP8 mice compared to that of RAO-treated SAMP8 mice.

Related Edges 9

• bp(GO:learning) negativeCorrelation p(HGNC:GSK3B)
• bp(GO:memory) negativeCorrelation p(HGNC:GSK3B)
• bp(MESH:"Oxidative Stress") positiveCorrelation p(HGNC:GSK3B)
• p(HGNC:NFE2L2) increases p(ECCODE:"2.5.1.18")
• p(HGNC:GSK3B) decreases p(HGNC:NFE2L2)
• p(HGNC:GSK3B) positiveCorrelation bp(MESH:"Oxidative Stress")
• p(HGNC:GSK3B) negativeCorrelation bp(GO:learning)
• act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231))
• act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235))

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---