p(HGNC:DAPK1) increases sec(p(HGNC:APP, frag("672_711")))

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PubMed:27094130

DAPK1, but not its kinase deficient mutant (K42A), significantly increased human Aβ secretion in neuronal cell culture models. Moreover, knockdown of DAPK1 expression or inhibition of DAPK1 catalytic activity significantly decreased Aβ secretion. Furthermore, DAPK1, but not K42A, triggered Thr668 phosphorylation of APP, which may initiate and facilitate amyloidogenic APP processing leading to the generation of Aβ.

Related Edges 5

• sec(p(HGNC:APP, frag("672_711"))) positiveCorrelation act(p(HGNC:DAPK1), ma(kin))
• sec(p(HGNC:APP, frag("672_713"))) positiveCorrelation act(p(HGNC:DAPK1), ma(kin))
• p(HGNC:DAPK1) increases sec(p(HGNC:APP, frag("672_713")))
• act(p(HGNC:DAPK1), ma(kin)) positiveCorrelation sec(p(HGNC:APP, frag("672_713")))
• act(p(HGNC:DAPK1), ma(kin)) positiveCorrelation sec(p(HGNC:APP, frag("672_711")))

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