g(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease")

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PubMed:30444369

Genetics have a role to play within AD; patients with a mutation in Amyloid Precursor Protein (APP), which results in overproduction of Aβ, will experience early onset AD. 36 Patients with a mutation in Apolipoprotein E4 (APOE4), which affects the clearance of Aβ, will experience late onset AD.

Related Edges 3

• g(HBP:"APOE e4") decreases deg(p(HGNC:APP))
• g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease")
• g(HGNC:APP, var("?")) increases p(HGNC:MAPT)

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