act(p(HGNC:GRIN1)) decreases a(MESH:Synapses)

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PubMed:29196815

Excessive activation of NMDAR by soluble AβOs triggers disproportionate influx of Ca2+ into neurons, which leads to excitotoxicity, mitochondrial dysfunction, and loss of synapses (Zhao et al. 2004).

Related Edges 4

• a(HBP:HBP00074) increases act(p(HGNC:GRIN1))
• act(p(HGNC:GRIN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:"intracellular part"))
• act(p(HGNC:GRIN1)) increases bp(HBP:HBP00068)
• act(p(HGNC:GRIN1)) increases bp(HBP:HBP00037)

MeSH

Extracellular Space

Cell Ontology (CL)

neuron

Confidence

Medium

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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