bp(GO:"ERK1 and ERK2 cascade") increases bp(GO:"apoptotic process")

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PubMed:19293145

Furthermore, nicotinic activation of ERK-1/2 promotes survival of cultured murine spinal cord neurons, and the blocking of ERK-1 prevents nicotine’s antiapoptotic action (Toborek et al., 2007). Likewise, the alpha7-specific agonist A-582941 induces phosphorylation of ERK-1/2 in PC12 cells and in mouse brain, and this is completely blocked by the mitogen-activated protein kinase 1 inhibitor SL327 (Bitner et al., 2007).

Related Edges 4

• a(CHEBI:"SL-327") decreases act(a(MESH:"A-582941"))
• a(CHEBI:nicotine) increases bp(GO:"ERK1 and ERK2 cascade")
• a(MESH:"A-582941") increases p(HGNC:MAPK3, pmod(Ph))
• a(MESH:"A-582941") increases p(HGNC:MAPK1, pmod(Ph))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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