p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422))

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PubMed:23294633

We studied underlying pathomechanisms in tauopathies using pR5 mice that express the P301L tau mutation found in familial forms of frontotemporal dementia. In a longitudinal study we investigated the functional status of glycogen synthase kinase-3 and correlated it with the appearance of distinct tau phospho-epitopes. Neurons displaying increases in activating phosphorylation of glycogen synthase kinase-3α/β at tyrosine 279/216 also showed an intense rather than moderate AT8 (phospho-Ser202/Thr205 tau) immunoreactivity, and immunoreactivity for AT100 (phospho-Ser212/Thr214 tau) and phosphorylated Ser422, phospho-epitopes associated with fibrillar tau pathology.

Related Edges 13

• a(HBP:"Tau epitope, AT100") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
• p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
• p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
• p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
• p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 279))
• p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 216))
• p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
• p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205))
• p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation a(HBP:"Tau epitope, AT100")
• p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
• p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) increases act(p(MGI:Gsk3b), ma(kin))
• p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
• p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) increases act(p(MGI:Gsk3b), ma(kin))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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