path(MESH:"Alzheimer Disease") association bp(GO:learning)

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PubMed:19293145

APP and APP/presenilin-1 (PS-1) mice do not show neurodegeneration (Irizarry et al., 1997) and yet show several features of AD, including accumulation of plaques and defects in learning (Hsiao et al., 1996), suggesting that many features of AD are not the result of neuronal loss. These animals nonetheless have swollen cholinergic nerve terminals at 12 months, suggesting defective nerve sprouting (Hernandez et al., 2001).

Related Edges 9

• a(CHEBI:"amyloid-beta") association path(MESH:"Alzheimer Disease")
• a(CHEBI:"amyloid-beta") causesNoChange path(HBP:Neurodegeneration)
• bp(GO:learning) association path(MESH:"Alzheimer Disease")
• p(HGNC:PSEN1) causesNoChange path(HBP:Neurodegeneration)
• p(HGNC:PSEN1) association path(MESH:"Alzheimer Disease")
• path(MESH:"Alzheimer Disease") association path(MESH:"Plaque, Amyloid")
• path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta")
• path(MESH:"Alzheimer Disease") association p(HGNC:PSEN1)
• path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease")

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