p(MESH:Proteins, pmod(HBP:misfolding)) increases p(HGNC:SQSTM1)

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PubMed:18930136

Cellular stresses such as polyQ expression, proteasome impairment, oxidative stress, and increased misfolded protein burden activate transcription and translation of p62, suggesting that it functions broadly in stress situations [83,84]

Related Edges 3

• bp(GO:"cellular response to stress") increases p(HGNC:SQSTM1)
• bp(GO:"response to oxidative stress") increases p(HGNC:SQSTM1)
• act(complex(GO:"proteasome complex")) decreases p(HGNC:SQSTM1)

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