act(p(HGNC:RAB5A)) decreases bp(GO:endocytosis)

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PubMed:22908190

Pathological Rab5 activation driving endocytic dysfunction in AD may negatively impact longterm potentiation (LTP) and long-term depression (LTD) aspects of synaptic plasticity closely associated with learning and memory (Kessels et al. 2009)

Related Edges 6

• bp(GO:"long-term synaptic depression") negativeCorrelation act(p(HGNC:RAB5A))
• bp(GO:"long-term synaptic potentiation") negativeCorrelation act(p(HGNC:RAB5A))
• bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease")
• act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic potentiation")
• act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic depression")
• path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis)

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