path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7)

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PubMed:19293145

Thus, predominantly alpha4 and alpha7 subunits, and to a lesser extent alpha3 subunits, are lost in AD, although there are tissue-specific differences to this pattern, such as the upregulation of nAChRs on astrocytes.

Related Edges 3

• path(MESH:"Alzheimer Disease") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
• path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3)

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