act(p(HGNC:GSK3B)) decreases act(p(HGNC:LCMT1))

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PubMed:24653673

For instance, activated GSK3β has been reported to induce PP2A inactivation via several mechanisms: phosphorylation of PP2A on Tyr307 (Yao et al.,2011); demethylation of PP2A on Leu309 through inhibition of LCMT1 and up-regulation of PME1 (Yao et al.,2012); and accumulation of I2 PP2A (Liu et al.,2008a).

Related Edges 14

• act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET)
• act(p(HGNC:GSK3B)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
• act(p(HGNC:GSK3B)) increases p(FPLX:PPP2, pmod(Ph, Tyr, 307))
• act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
• act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CB, pmod(Me, Leu, 309))
• act(p(HGNC:GSK3B)) increases act(p(HGNC:PPME1))
• act(p(HGNC:GSK3B)) increases p(HGNC:SET)
• p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
• p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309))
• act(p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
• p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex"))
• p(FPLX:PPP2, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
• p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex"))
• p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex"))

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