a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly")

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PubMed:22122372

Studies have demonstrated that Abeta overproduction leads to neurotoxicity, neuronal tangle formation, synaptic damage and eventually neuron loss in the pathologically affected brain regions (Selkoe 1998; Shankar and Walsh 2009)

Related Edges 3

• a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity")
• a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death")
• a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061)

Confidence

High

MeSH

Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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