p(HGNC:UBE3A) increases deg(p(HGNC:ARC))

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PubMed:22908190

This and numerous related findings suggest that degradation of certain critical proteins by the UPS is required during long-term memory formation. One of these proteins is arc, a negative regulator of synaptic strength that promotes the internalization of AMPA receptors and is degraded via the E3 ligase, UBE3A (Greer et al. 2010).

Related Edges 3

• bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:ARC))
• bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"long-term memory")
• p(HGNC:ARC) regulates bp(GO:"synapse maturation")

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