a(CHEBI:harmine) increases p(HGNC:MME)

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PubMed:28250274

Neprilysin, a major Aß-degrading enzyme, was downregulated in DS patient-derived fibroblasts. Treatment with harmine, a DYRK1A inhibitor and gene knockdown of DYRK1A, upregulated neprilysin in fibroblasts.

Related Edges 4

• a(CHEBI:harmine) decreases p(HGNC:DYRK1A)
• p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MME)
• p(HGNC:MME) negativeCorrelation p(HGNC:DYRK1A)
• p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta"))

MeSH

Down Syndrome

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